姓       名：

杨冠

职称及职务：

研究员，博导

招生专业：

研 究 方 向：

基因编辑动物模型

联系方式：

邮  箱：yangguan@bmi.ac.cn；yogopop3@163.com

电  话：010-61777228

主要科研领域与方向：

北京市科技新星、青年科技英才，主要以基因编辑小鼠为模型，研究烈性传染病动物模型和致病机制、骨骼发育与损伤修复机制等，以第一/通讯作者（含共同署名）在 Science、Cell、Cell Research、Bone Research、Cell discovery等期刊发表研究论文20篇（总IF>320，引用>2500次）。期望招收生物医学专业的研究生，共同研制人类重大疾病相关的基因编辑小鼠模型，探讨组织干细胞在器官发育和重大疾病中的作用及细胞命运决定机制。

代表性论文（*共同通讯作者，#共同第一作者）：

1. Guan Yang*#, Qi He#, Xiaoxiao Guo#, Rong-Yu Li#, Jingting Lin, Yiming Lang, Wanyu Tao Wenjia Liu Huisang Lin, Shilai Xing, Yini Qi, Zhongliang Xie, Jing-Dong J Han, Bin Zhou*, Yan Teng*, Xiao Yang*. Identification of the metaphyseal skeletal stem cell building trabecular bone. Science Advances. 2024, 23;10(8):eadl2238.

2. Xingyao Huang#, Qi Chen# , Mengxu Sun#, Hangyu Zhou#, Qing Ye#, Wu Chen#, Jinyu Peng, Yini Qi, Junqiong Zhai, Ying Tian, Zixin Liu, Yijiao Huang, Yongqiang Deng, Xiaofeng Li, Aiping Wu, Xiao Yang, Guan Yang*, Yongyi Shen*, Chengfeng Qin*. A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity. Cell Discovery. 2023 Jun 17;9(1):59.  

3. Hongjing Gu#, Qi Chen#, Guan Yang#, Lei He#, Hang Fan#, Yongqiang Deng#, Yanxiao Wang, Yue Teng , Zhongpeng Zhao, Yujun Cui, Yuchang Li, Xiaofeng Li, Jiangfan Li, Nana Zhang, Xiaolan Yang, Shaolong Chen, Yan Guo, Guangyu Zhao, Xiliang Wang, Deyan Luo, Hui Wang, Xiao Yang, Yan Li, Gencheng Han, Yuxian He, Xiaojun Zhou, Shusheng Geng, Xiaoli Sheng, Shibo Jiang*, Shihui Sun*, Chengfeng Qin*, Yusen Zhou*. Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy. Science. 2020 Jul 30;eabc4730.

4. Nana Zhang#, Xiaofeng Li#, Yongqiang Deng#, Hui Zhao#, Yijiao Huang#, Guan Yang#, Weijin Huang#, Peng Gao, Chao Zhou, Rongrong Zhang, Yan Guo, Shihui Sun, Hang Fan, Shulong Zu, Qi Chen, Qi He, Tianshu Cao, Xingyao Huang, Hongying Qiu, Jianhui Nie, Yuhang Jiang, Huayuan Yan, Qing Ye, Xia Zhong, Xialin Xue, Zhenyu Zha, Dongsheng Zhou, Xiao Yang, Youchun Wang*, Bo Ying*, Chengfeng Qin*. A thermostable mRNA vaccine against COVID-19. Cell. 2020 Sep 3;182(5):1271-1283.

5. Jing Xie#, Jingting Lin#, Min Wei, Yan Teng, Qi He, Guan Yang* and Xiao Yang*. Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice. Bone Research. 2019 Aug 5; 7:23.