研究团队成员列表

李栋

发布时间: 2024-07-30 16:21:08

姓       名:

李栋

职称及职务:

研究员,博导

招生专业:

 

生物信息学

 

研 究 方 向:

生命组学大数据知识发现的理论与技术研究

联系方式:

邮  箱:lidong.bprc@foxmail.com

电  话:61777057, 13810965690

主要科研领域与方向:

从事生命组学大数据知识挖掘理论与技术的研究。承担国家精准医学重点专项、国家科技合作与交流重点专项、国家自然科学金面上项目等国家级课题6项。在Nature communications等期刊发表第一/通讯作者署名SCI论文43篇,研发生物信息分析工具论文为SCI高被引,为国内外提供数据分析服务40余万次,获软件著作权28项。国际期刊Analytical Biochemistry, PROTEOMICSFrontiers in Pharmacology编委,第七批北京市优秀青年人才,北京市青年拔尖人才,获国家科技进步创新团队奖等国家级、省部级奖励5次。指导研究生1人次获优秀博士论文,2人次获院优秀研究生论文,2019年优秀教师。

代表性论文(*共同通讯作者,#共同第一作者)

1. Liu Y, Li D, Zhang X, Xia S, Qu Y, Ling X, Li Y, Kong X, Zhang L, Cui CP*, Li D*. A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions. Nat Commun. 2024 May 28;15(1):4519.

2. Kong X, Liu C, Zhang Z, Cheng M, Mei Z, Li X, Liu P, Diao L, Ma Y, Jiang P, Kong X, Nie S, Guo Y, Wang Z, Zhang X, Wang Y, Tang L, Guo S*, Liu Z*, Li D*. BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins. Nucleic Acids Res. 2024; 52:D1110.

3. Wang X, Li Y, He M, Kong X, Jiang P, Liu X, Diao L, Zhang X, Li H, Ling X, Xia S, Liu Z, Liu Y, Cui C, Wang Y, Tang L, Zhang L*, He F*, and Li D*. UbiBrowser 2.0: a comprehensive resource for proteome-wide ubiquitin ligase/deubiquitinase-substrate interactions in eukaryotic species. Nucleic Acids Research, 2022,50: D719–D728

4. Kong X, Diao L, Jiang P, Nie S, Guo S*, Li D*. DDK-Linker: a network-based strategy identifies disease signals by linking high-throughput omics datasets to disease knowledge. Brief Bioinform. 2024; 25:bbae111.

5. Diao L, He M, Xu B, Chen L, Wang Z, Yang Y, Xia S, Hu S*, Guo S*, Li D*. Identification of Proteome-Based Immune Subtypes of Early Hepatocellular Carcinoma and Analysis of Potential Metabolic Drivers. Mol Cell Proteomics. 2024; 23:100686.

姓       名:

李栋

职称及职务:

研究员,博导

招生专业:

 

生物信息学

 

研 究 方 向:

生命组学大数据知识发现的理论与技术研究

联系方式:

邮  箱:lidong.bprc@foxmail.com

电  话:61777057, 13810965690

主要科研领域与方向:

从事生命组学大数据知识挖掘理论与技术的研究。承担国家精准医学重点专项、国家科技合作与交流重点专项、国家自然科学金面上项目等国家级课题6项。在Nature communications等期刊发表第一/通讯作者署名SCI论文43篇,研发生物信息分析工具论文为SCI高被引,为国内外提供数据分析服务40余万次,获软件著作权28项。国际期刊Analytical Biochemistry, PROTEOMICSFrontiers in Pharmacology编委,第七批北京市优秀青年人才,北京市青年拔尖人才,获国家科技进步创新团队奖等国家级、省部级奖励5次。指导研究生1人次获优秀博士论文,2人次获院优秀研究生论文,2019年优秀教师。

代表性论文(*共同通讯作者,#共同第一作者)

1. Liu Y, Li D, Zhang X, Xia S, Qu Y, Ling X, Li Y, Kong X, Zhang L, Cui CP*, Li D*. A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions. Nat Commun. 2024 May 28;15(1):4519.

2. Kong X, Liu C, Zhang Z, Cheng M, Mei Z, Li X, Liu P, Diao L, Ma Y, Jiang P, Kong X, Nie S, Guo Y, Wang Z, Zhang X, Wang Y, Tang L, Guo S*, Liu Z*, Li D*. BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins. Nucleic Acids Res. 2024; 52:D1110.

3. Wang X, Li Y, He M, Kong X, Jiang P, Liu X, Diao L, Zhang X, Li H, Ling X, Xia S, Liu Z, Liu Y, Cui C, Wang Y, Tang L, Zhang L*, He F*, and Li D*. UbiBrowser 2.0: a comprehensive resource for proteome-wide ubiquitin ligase/deubiquitinase-substrate interactions in eukaryotic species. Nucleic Acids Research, 2022,50: D719–D728

4. Kong X, Diao L, Jiang P, Nie S, Guo S*, Li D*. DDK-Linker: a network-based strategy identifies disease signals by linking high-throughput omics datasets to disease knowledge. Brief Bioinform. 2024; 25:bbae111.

5. Diao L, He M, Xu B, Chen L, Wang Z, Yang Y, Xia S, Hu S*, Guo S*, Li D*. Identification of Proteome-Based Immune Subtypes of Early Hepatocellular Carcinoma and Analysis of Potential Metabolic Drivers. Mol Cell Proteomics. 2024; 23:100686.